A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplantation

Predicting immediate and subsequent graft function is important in clinical decision-making around kidney transplantation, but is difficult using available approaches. Here we have evaluated urinary microRNAs as biomarkers in this context. Profiling of 377 microRNAs in the first urine passed post-tr...

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.3584-3584, Article 3584
Main Authors: Khalid, Usman, Newbury, Lucy J., Simpson, Kate, Jenkins, Robert H., Bowen, Timothy, Bates, Lucy, Sheerin, Neil S., Chavez, Rafael, Fraser, Donald J.
Format: Article
Language:English
Subjects:
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Adolescent
Adult
Aged
Biomarkers
Biomarkers - urine
Child
Cohort Studies
Decision making
Delayed Graft Function - etiology
Delayed Graft Function - urine
Female
Humanities and Social Sciences
Humans
Immunity (Disease)
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney transplants
Male
MicroRNAs
MicroRNAs - urine
Middle Aged
miRNA
multidisciplinary
Science
Science (multidisciplinary)
Transplants & implants
Urine
Young Adult
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Summary:Predicting immediate and subsequent graft function is important in clinical decision-making around kidney transplantation, but is difficult using available approaches. Here we have evaluated urinary microRNAs as biomarkers in this context. Profiling of 377 microRNAs in the first urine passed post-transplantation identified 6 microRNAs, confirmed to be upregulated by RT-qPCR in an expanded cohort (miR-9, -10a, -21, -29a, -221, and -429, n = 33, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-38642-3