Schistosoma japonicum -Associated Colorectal Cancer: A Review

is a digenetic blood fluke that has been implicated in the carcinogenesis of several human malignancies, notably liver and colorectal cancer (CRC). -associated colorectal cancer (SACC) is a distinct subtype with biological behavior analogous to colitis-induced CRC. The clinicopathological characteri...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2019-03, Vol.100 (3), p.501-505
Main Author: Hamid, Hytham K S
Format: Article
Language:English
Subjects:
Animals
China
Colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Colorectal Neoplasms - parasitology
Health risk assessment
Humans
Review
Schistosoma japonicum
Schistosomiasis japonica - complications
Schistosomiasis japonica - epidemiology
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Summary:is a digenetic blood fluke that has been implicated in the carcinogenesis of several human malignancies, notably liver and colorectal cancer (CRC). -associated colorectal cancer (SACC) is a distinct subtype with biological behavior analogous to colitis-induced CRC. The clinicopathological characteristics of SACC include young age at diagnosis, predominance among males, a strong predilection for the sigmoid colon and rectum, multifocal distribution, frequent mucinous histology, and poor prognosis. In addition to chronic inflammation, immunomodulation, and schistosomal toxins, bacterial coinfection appears to play an important role in the carcinogenic process. The present review provides the most recent updates on epidemiology, pathobiology, and clinical and prognostic features pertaining to SACC.
ISSN:0002-9637
1476-1645
1476-1645
DOI:10.4269/ajtmh.18-0807