pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems

This study describes the design and synthesis of organic⁻inorganic hybrid hydrogels based on an interpenetrating polymer network (IPN) composed of polyaspartic acid crosslinked by graphene nanosheets as the primary network and poly(acrylamide-co-acrylic acid) as the secondary network. Silver, copper...

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Bibliographic Details
Published in:Polymers 2018-06, Vol.10 (6), p.660
Main Authors: Sattari, Shabnam, Dadkhah Tehrani, Abbas, Adeli, Mohsen
Format: Article
Language:English
Subjects:
Acids
Acrylamide
Acrylic acid
Bacteria
Cellulose acetate
Chemical synthesis
Cobalt
Controlled release
Copper oxides
Crosslinking
Drug delivery systems
Drugs
E coli
Fourier transforms
Gels
Graphene
Hydrogels
Interpenetrating networks
Nanocomposites
Nanoparticles
Nitrates
Polymers
Wound healing
Zinc oxide
Zinc oxides
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Summary:This study describes the design and synthesis of organic⁻inorganic hybrid hydrogels based on an interpenetrating polymer network (IPN) composed of polyaspartic acid crosslinked by graphene nanosheets as the primary network and poly(acrylamide-co-acrylic acid) as the secondary network. Silver, copper oxide, and zinc oxide nanoparticles were formed within the gel matrix, and the obtained hydrogel was applied to a load and controlled release of curcumin. The loading of curcumin and the release of this drug from the gels depended on the nanoparticle's (NP's) content of hydrogels as well as the pH of the medium. The synthesized hydrogels showed antibacterial activity against and bacteria. The ability of the synthesized hydrogels to incapacitate bacteria and their loading capacity and controlled release of curcumin qualify them for future therapies such as wound-dressing applications.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym10060660