TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering suc...

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.3877-3877, Article 3877
Main Authors: Chou, Po-Hao, Liao, Wei-Chao, Tsai, Kuo-Wang, Chen, Ku-Chung, Yu, Jau-Song, Chen, Ting-Wen
Format: Article
Language:English
Subjects:
631/114/129/2043
631/114/1305
631/337/2019
692/53/2422
Cancer
Clinical outcomes
Decision making
Gene expression
Humanities and Social Sciences
Medical prognosis
miRNA
multidisciplinary
Patients
Prognosis
Science
Science (multidisciplinary)
Therapeutic applications
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Summary:Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/ .
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-40629-z