Systematic review of treatment strategy for recurrent hepatocellular carcinoma: Salvage liver transplantation or curative locoregional therapy

The aim of our systematic review was to compare the efficacy of salvage liver transplantation (SLT) versus curative locoregional therapy (CLRT) for patients with recurrent hepatocellular carcinoma (HCC). Studies comparing the SLT with CLRT for patients with recurrent HCC were selected from database...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-02, Vol.98 (8), p.e14498-e14498
Main Authors: Wang, Hong-Liang, Mo, Dun-Chang, Zhong, Jian-Hong, Ma, Liang, Wu, Fei-Xiang, Xiang, Bang-De, Li, Le-Qun
Format: Article
Language:English
Subjects:
Systematic Review and Meta-Analysis
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Summary:The aim of our systematic review was to compare the efficacy of salvage liver transplantation (SLT) versus curative locoregional therapy (CLRT) for patients with recurrent hepatocellular carcinoma (HCC). Studies comparing the SLT with CLRT for patients with recurrent HCC were selected from database of PubMed, EMBASE, and Cochrane library. The outcomes including overall survival, disease-free survival, and complications were abstracted. Individual and pooled odds ratio (OR) with 95% confidence interval of each outcome was analyzed. Seven retrospective studies involving 840 patients were included. There is no difference between SLT and CLRT group regarding the1- and 3-year overall survival rates. However, the 5-year overall survival and 1-, 3-, 5-year disease-free survival were significantly higher after SLT than after CLRT (OR = 1.62, 95% CI 1.09-2.39, P = .02; OR = 4.08, 95% CI 1.95-8.54, P = .0002; OR = 3.63, 95% CI 2.21-5.95, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000014498