Prelimbic and infralimbic cortical inactivations attenuate contextually driven discriminative responding for reward

The infralimbic (IL) and prelimbic (PL) cortices of the medial prefrontal cortex (mPFC) have been shown to differentially control context-dependent behavior, with the PL implicated in the expression of contextually conditioned fear and drug-seeking, and the IL in the suppression of these behaviors....

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.3982-3982, Article 3982
Main Authors: Riaz, Sadia, Puveendrakumaran, Pugaliya, Khan, Dinat, Yoon, Sharon, Hamel, Laurie, Ito, Rutsuko
Format: Article
Language:English
Subjects:
631/378/1595/2618
631/378/1662
631/378/1788
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Auditory discrimination
Baclofen
Behavior
Fear conditioning
Humanities and Social Sciences
Memory
multidisciplinary
Muscimol
Nose
Prefrontal cortex
Reinforcement
Science
Science (multidisciplinary)
Sucrose
γ-Aminobutyric acid
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Summary:The infralimbic (IL) and prelimbic (PL) cortices of the medial prefrontal cortex (mPFC) have been shown to differentially control context-dependent behavior, with the PL implicated in the expression of contextually conditioned fear and drug-seeking, and the IL in the suppression of these behaviors. However, the roles of these subregions in contextually driven natural reward-seeking remain relatively underexplored. The present study further examined the functional dichotomy within the mPFC in the contextual control over cued reward-seeking, using a contextual biconditional discrimination (CBD) task. Rats were first trained to emit a nose poke response to the presentation of an auditory stimulus (e.g., X) for the delivery of sucrose reward, and to withhold a nose poke response to the presentation of another auditory stimulus (e.g., Y) in a context-specific manner (e.g. Context A: X+, Y−; Context B: X−, Y+). Following acquisition, rats received bilateral microinjections of GABA receptor agonists (muscimol and baclofen), or saline into the IL or PL, prior to a CBD training session and a probe test (under extinction conditions). Both IL and PL inactivation resulted in robust impairment in CBD performance, indicating that both subregions are involved in the processing of appetitively motivated contextual memories in reward-seeking.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-40532-7