Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors

Purpose Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients w...

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Bibliographic Details
Published in:The neuroradiology journal 2019-04, Vol.32 (2), p.108-114
Main Authors: Ashrafi, Farzad, Taheri, Morteza Sanei, Farzaneh, Aida, Behnam, Behdad, Ahmadi, Mehran Arab
Format: Article
Language:English
Subjects:
Cerebrovascular Diseases
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Summary:Purpose Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients with cardiovascular risk factors in a sample of the Iranian population. Materials and methods This study was conducted on a total number of 156 normal subjects aged 30–74 years with cardiovascular risk factors. We used the Framingham general cardiovascular risk factors prediction model to calculate the likelihood of each risk factor. The total number of lacunar infarcts and the volume of white matter hyperintensity lesion were calculated in brain magnetic resonance imaging. Cognition status was assessed using the Montreal Cognitive Assessment questionnaire. Results An adverse association was revealed between Montreal Cognitive Assessment score and different cardiovascular risk profiles including the Framingham body mass index score (p 
ISSN:1971-4009
2385-1996
DOI:10.1177/1971400919825862