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Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors
Purpose Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients w...
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| Published in: | The neuroradiology journal 2019-04, Vol.32 (2), p.108-114 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c434t-328b021769441436c106ed0cf20b81038588f42dec32e14e5d6ad401193f80523 |
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| cites | cdi_FETCH-LOGICAL-c434t-328b021769441436c106ed0cf20b81038588f42dec32e14e5d6ad401193f80523 |
| container_end_page | 114 |
| container_issue | 2 |
| container_start_page | 108 |
| container_title | The neuroradiology journal |
| container_volume | 32 |
| creator | Ashrafi, Farzad Taheri, Morteza Sanei Farzaneh, Aida Behnam, Behdad Ahmadi, Mehran Arab |
| description | Purpose
Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients with cardiovascular risk factors in a sample of the Iranian population.
Materials and methods
This study was conducted on a total number of 156 normal subjects aged 30–74 years with cardiovascular risk factors. We used the Framingham general cardiovascular risk factors prediction model to calculate the likelihood of each risk factor. The total number of lacunar infarcts and the volume of white matter hyperintensity lesion were calculated in brain magnetic resonance imaging. Cognition status was assessed using the Montreal Cognitive Assessment questionnaire.
Results
An adverse association was revealed between Montreal Cognitive Assessment score and different cardiovascular risk profiles including the Framingham body mass index score (p |
| doi_str_mv | 10.1177/1971400919825862 |
| format | article |
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Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients with cardiovascular risk factors in a sample of the Iranian population.
Materials and methods
This study was conducted on a total number of 156 normal subjects aged 30–74 years with cardiovascular risk factors. We used the Framingham general cardiovascular risk factors prediction model to calculate the likelihood of each risk factor. The total number of lacunar infarcts and the volume of white matter hyperintensity lesion were calculated in brain magnetic resonance imaging. Cognition status was assessed using the Montreal Cognitive Assessment questionnaire.
Results
An adverse association was revealed between Montreal Cognitive Assessment score and different cardiovascular risk profiles including the Framingham body mass index score (p < 0.001) and the Framingham lipid score (p < 0.001). The total volume of white matter hyperintensity was negatively associated with total Montreal Cognitive Assessment cognition score (p < 0.001). Our study also showed an adverse association between total number of lacunar infarcts and total Montreal Cognitive Assessment cognition score (p = 0.038) and with some cognition components including memory (p = 0.013), attention (p = 0.037), abstraction (p = 0.046), and orientation (p = 0.002).
Conclusion
Periventricular lesions are associated with impaired memory, language, and visuoconstruction while subcortical lesions are associated with impairment in naming, attention, language, and abstraction functions in normal subjects with cardiovascular risk factors but without cardiovascular or cerebrovascular disorders.</description><identifier>ISSN: 1971-4009</identifier><identifier>EISSN: 2385-1996</identifier><identifier>DOI: 10.1177/1971400919825862</identifier><identifier>PMID: 30674224</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Cerebrovascular Diseases</subject><ispartof>The neuroradiology journal, 2019-04, Vol.32 (2), p.108-114</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019 2019 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-328b021769441436c106ed0cf20b81038588f42dec32e14e5d6ad401193f80523</citedby><cites>FETCH-LOGICAL-c434t-328b021769441436c106ed0cf20b81038588f42dec32e14e5d6ad401193f80523</cites><orcidid>0000-0002-8881-9058</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410460/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766</link.rule.ids></links><search><creatorcontrib>Ashrafi, Farzad</creatorcontrib><creatorcontrib>Taheri, Morteza Sanei</creatorcontrib><creatorcontrib>Farzaneh, Aida</creatorcontrib><creatorcontrib>Behnam, Behdad</creatorcontrib><creatorcontrib>Ahmadi, Mehran Arab</creatorcontrib><title>Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors</title><title>The neuroradiology journal</title><description>Purpose
Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients with cardiovascular risk factors in a sample of the Iranian population.
Materials and methods
This study was conducted on a total number of 156 normal subjects aged 30–74 years with cardiovascular risk factors. We used the Framingham general cardiovascular risk factors prediction model to calculate the likelihood of each risk factor. The total number of lacunar infarcts and the volume of white matter hyperintensity lesion were calculated in brain magnetic resonance imaging. Cognition status was assessed using the Montreal Cognitive Assessment questionnaire.
Results
An adverse association was revealed between Montreal Cognitive Assessment score and different cardiovascular risk profiles including the Framingham body mass index score (p < 0.001) and the Framingham lipid score (p < 0.001). The total volume of white matter hyperintensity was negatively associated with total Montreal Cognitive Assessment cognition score (p < 0.001). Our study also showed an adverse association between total number of lacunar infarcts and total Montreal Cognitive Assessment cognition score (p = 0.038) and with some cognition components including memory (p = 0.013), attention (p = 0.037), abstraction (p = 0.046), and orientation (p = 0.002).
Conclusion
Periventricular lesions are associated with impaired memory, language, and visuoconstruction while subcortical lesions are associated with impairment in naming, attention, language, and abstraction functions in normal subjects with cardiovascular risk factors but without cardiovascular or cerebrovascular disorders.</description><subject>Cerebrovascular Diseases</subject><issn>1971-4009</issn><issn>2385-1996</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1UU1rGzEUFKWhNqnvOb4_sK2-Vqu9BIJJG4Mhl_S8yNq3tpy1tEiyTX9H_nDkuhRa6Ls8mHkzMG8IuWP0C2NN85W1DZOUtqzVvNaKfyBzLnRdsbZVH8n8QlcXfkYWKe1pGaHbWupPZCaoaiTnck7elmHrXXYnhOHobXbBJzC-h_POZYSDyRkjjJh-EcEXZOsxOwsRU_DGWwRXMEzgPBhI5jCNCGEAH-LBjLCKxjvjYQrTcTQXfzi7vANrYu_CySRb4AjRpVcYjM0hps_kZjBjwsXvfUt-fHt8WT5V6-fvq-XDurJSyFwJrjeUs0a1UjIplGVUYU_twOlGsxK21nqQvEcrODKJda9MLyljrRg0rbm4JfdX3-m4OWBv0edoxm6KJVD82QXjur8Z73bdNpw6JRmVihYDejWwMaQUcfijZbS7dNT921GRVFdJKj_r9uEYfYn4__t3gSCS6w</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Ashrafi, Farzad</creator><creator>Taheri, Morteza Sanei</creator><creator>Farzaneh, Aida</creator><creator>Behnam, Behdad</creator><creator>Ahmadi, Mehran Arab</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8881-9058</orcidid></search><sort><creationdate>20190401</creationdate><title>Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors</title><author>Ashrafi, Farzad ; Taheri, Morteza Sanei ; Farzaneh, Aida ; Behnam, Behdad ; Ahmadi, Mehran Arab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-328b021769441436c106ed0cf20b81038588f42dec32e14e5d6ad401193f80523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cerebrovascular Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashrafi, Farzad</creatorcontrib><creatorcontrib>Taheri, Morteza Sanei</creatorcontrib><creatorcontrib>Farzaneh, Aida</creatorcontrib><creatorcontrib>Behnam, Behdad</creatorcontrib><creatorcontrib>Ahmadi, Mehran Arab</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The neuroradiology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashrafi, Farzad</au><au>Taheri, Morteza Sanei</au><au>Farzaneh, Aida</au><au>Behnam, Behdad</au><au>Ahmadi, Mehran Arab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors</atitle><jtitle>The neuroradiology journal</jtitle><date>2019-04-01</date><risdate>2019</risdate><volume>32</volume><issue>2</issue><spage>108</spage><epage>114</epage><pages>108-114</pages><issn>1971-4009</issn><eissn>2385-1996</eissn><abstract>Purpose
Due to a suggestive three-way relationship between brain structural disorders, microvascular lesions, and cognitive impairments, we aimed to examine the association of the volume and number of white matter hyperintensity lesions and lacunar infarcts with cognitive impairment among patients with cardiovascular risk factors in a sample of the Iranian population.
Materials and methods
This study was conducted on a total number of 156 normal subjects aged 30–74 years with cardiovascular risk factors. We used the Framingham general cardiovascular risk factors prediction model to calculate the likelihood of each risk factor. The total number of lacunar infarcts and the volume of white matter hyperintensity lesion were calculated in brain magnetic resonance imaging. Cognition status was assessed using the Montreal Cognitive Assessment questionnaire.
Results
An adverse association was revealed between Montreal Cognitive Assessment score and different cardiovascular risk profiles including the Framingham body mass index score (p < 0.001) and the Framingham lipid score (p < 0.001). The total volume of white matter hyperintensity was negatively associated with total Montreal Cognitive Assessment cognition score (p < 0.001). Our study also showed an adverse association between total number of lacunar infarcts and total Montreal Cognitive Assessment cognition score (p = 0.038) and with some cognition components including memory (p = 0.013), attention (p = 0.037), abstraction (p = 0.046), and orientation (p = 0.002).
Conclusion
Periventricular lesions are associated with impaired memory, language, and visuoconstruction while subcortical lesions are associated with impairment in naming, attention, language, and abstraction functions in normal subjects with cardiovascular risk factors but without cardiovascular or cerebrovascular disorders.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30674224</pmid><doi>10.1177/1971400919825862</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8881-9058</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1971-4009 |
| ispartof | The neuroradiology journal, 2019-04, Vol.32 (2), p.108-114 |
| issn | 1971-4009 2385-1996 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6410460 |
| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list); PubMed Central |
| subjects | Cerebrovascular Diseases |
| title | Cognitive functions and white matter lesions on magnetic resonance images in a sample of normal Iranian population with cardiovascular risk factors |
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