Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats

• Published in: Nutrients 2019-01, Vol.11 (2), p.244
• Main Authors: Son, Hye-Yeon, Lee, Mak-Soon, Chang, Eugene, Kim, Seog-Young, Kang, Bori, Ko, Hyunmi, Kim, In-Hwan, Zhong, Qixin, Jo, Young-Hee, Kim, Chong-Tai, Kim, Yangha
• Format: Article
• Language: English
• Subjects: ABC transporters; Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Bile; Bile acids; Bioavailability; Biopolymers; blood serum; Cardiovascular disease; chemical degradation; cholesteremic effect; Cholesterol; Cholesterol, Dietary - administration & dosage; Cocoa; Curcumin; Emulsions - chemistry; encapsulation; enzymes; excretion; Fat metabolism; feces; Food; Fruits; functional foods; Garlic; gene expression; gene expression regulation; Green tea; Hesperidin; High density lipoprotein; high fat diet; Homeostasis; Hypercholesterolemia - drug therapy; ingredients; Intestine; Lipid metabolism; Lipids; liver; Low density lipoprotein; Male; Metabolism; Nanoemulsions; Nanostructures; Natural resources; Oil; oils; Particle size; Polyphenols; Quercetin; Quercetin - chemistry; Quercetin - therapeutic use; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium; Surface tension; Surfactants; Tea; Vegetable oils; water solubility
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11020244

Due to poor water solubility and high susceptibility to chemical degradation, the applications of quercetin have been limited. This study investigated the effects of pH on the formation of quercetin-loaded nanoemulsion (NQ) and compared the hypocholesterolemic activity between quercetin and NQ to utilize the quercetin as functional food ingredient. NQ particle size exhibited a range of 207⁻289 nm with polydispersity index range (