Roles of MicroRNA-34a in Epithelial to Mesenchymal Transition, Competing Endogenous RNA Sponging and Its Therapeutic Potential

MicroRNA-34a (miR-34a), a tumor suppressor, has been reported to be dysregulated in various human cancers. MiR-34a is involves in certain epithelial-mesenchymal transition (EMT)-associated signal pathways to repress tumorigenesis, cancer progression, and metastasis. Due to the particularity of miR-3...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-02, Vol.20 (4), p.861
Main Authors: Nie, Dongsong, Fu, Jiewen, Chen, Hanchun, Cheng, Jingliang, Fu, Junjiang
Format: Article
Language:English
Subjects:
Apoptosis
Autoimmune diseases
Autophagy
Biological activity
Breast cancer
Cardiovascular diseases
Cell growth
Cell Proliferation - genetics
Control theory
E-cadherin
Epithelial-Mesenchymal Transition - genetics
Feedback loops
Fibronectin
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Immune response
Liver cancer
Matrix metalloproteinase
Matrix metalloproteinases
Medical prognosis
Mesenchyme
Metastases
Metastasis
MicroRNAs
MicroRNAs - genetics
miRNA
Molecular Targeted Therapy
N-Cadherin
Neoplasms - genetics
Neoplasms - therapy
Ovarian cancer
p53 Protein
Phagocytosis
Polarity
Review
RNA - genetics
RNA, Long Noncoding - genetics
Senescence
Signal Transduction
Systematic review
Transcription factors
Tumors
Vimentin
α-Catenin
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Summary:MicroRNA-34a (miR-34a), a tumor suppressor, has been reported to be dysregulated in various human cancers. MiR-34a is involves in certain epithelial-mesenchymal transition (EMT)-associated signal pathways to repress tumorigenesis, cancer progression, and metastasis. Due to the particularity of miR-34 family in tumor-associated EMT, the significance of miR-34a is being increasingly recognized. Competing endogenous RNA (ceRNA) is a novel concept involving mRNA, circular RNA, pseudogene transcript, and long noncoding RNA regulating each other's expressions using microRNA response elements to compete for the binding of microRNAs. Studies showed that miR-34a is efficient for cancer therapy. Here, we provide an overview of the function of miR-34a in tumor-associated EMT. ceRNA hypothesis plays an important role in miR-34a regulation in EMT, cancer progression, and metastasis. Its potential roles and challenges as a microRNA therapeutic candidate are discussed. As the negative effect on cancer progression, miR-34a should play crucial roles in clinical diagnosis and cancer therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20040861