Hyaluronan-Chondroitin Sulfate Anomalous Crosslinking Due to Temperature Changes

Glycosaminoglycans are a wide class of biopolymers showing great lubricating properties due to their structure and high affinity to water. Two of them, hyaluronic acid and chondroitin sulfate, play an important role in articular cartilage lubrication. In this work, we present results of the all-atom...

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Bibliographic Details
Published in:Polymers 2018-05, Vol.10 (5), p.560
Main Authors: Andrysiak, Tomasz, Bełdowski, Piotr, Siódmiak, Jacek, Weber, Piotr, Ledziński, Damian
Format: Article
Language:English
Subjects:
Biopolymers
Cartilage
Chondroitin sulfate
Crosslinking
Glycosaminoglycans
Hyaluronic acid
Hydrogen bonds
Lubricating properties
Lubrication
Molecular chains
Molecular dynamics
Physiology
Stability
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Summary:Glycosaminoglycans are a wide class of biopolymers showing great lubricating properties due to their structure and high affinity to water. Two of them, hyaluronic acid and chondroitin sulfate, play an important role in articular cartilage lubrication. In this work, we present results of the all-atom molecular dynamics simulations of both molecules placed in water-based solution. To mimic changes of the physiological conditions, especially temperature, of the synovial fluid in joints under successive load (e.g., walking, jogging, jumping), simulations have been performed at different physiological temperatures in the range of 300 to 320 Kelvin (normal intra-articular temperature is 305 K). The stability of the biopolymeric network at equilibrium (isothermal and isobaric) conditions has been studied. To understand the process of physical crosslinking, the dynamics of intra- and intermolecular hydrogen bonds forming and breaking have been studied. The results show that following addition of chondroitin sulfate, hyaluronan creates more intermolecular hydrogen bonds than when in homogeneous solution. The presence of chondroitin in a hyaluronan network is beneficial as it may increase its stability. Presented data show hyaluronic acid and chondroitin sulfate as viscosity modifiers related to their crosslinking properties in different physicochemical conditions.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym10050560