Lag Phase Is a Dynamic, Organized, Adaptive, and Evolvable Period That Prepares Bacteria for Cell Division

Lag is a temporary period of nonreplication seen in bacteria that are introduced to new media. Despite latency being described by Müller in 1895, only recently have we gained insights into the cellular processes characterizing lag phase. This review covers literature to date on the transcriptomic, p...

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Bibliographic Details
Published in:Journal of bacteriology 2019-04, Vol.201 (7)
Main Author: Bertrand, Robert L
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Antibiotic tolerance
Antibiotics
Bacteria
Bacteria - growth & development
Bacteriology
Biological evolution
Cell Division
Culture Media - chemistry
Fitness
Food safety
Host-pathogen interactions
Lag phase
Latency
Literature reviews
Metabolomics
Microbiology
Minireview
Nutrients
Proteomics
Reproductive fitness
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Description
Summary:Lag is a temporary period of nonreplication seen in bacteria that are introduced to new media. Despite latency being described by Müller in 1895, only recently have we gained insights into the cellular processes characterizing lag phase. This review covers literature to date on the transcriptomic, proteomic, metabolomic, physiological, biochemical, and evolutionary features of prokaryotic lag. Though lag is commonly described as a preparative phase that allows bacteria to harvest nutrients and adapt to new environments, the implications of recent studies indicate that a refinement of this view is well deserved. As shown, lag is a dynamic, organized, adaptive, and evolvable process that protects bacteria from threats, promotes reproductive fitness, and is broadly relevant to the study of bacterial evolution, host-pathogen interactions, antibiotic tolerance, environmental biology, molecular microbiology, and food safety.
ISSN:0021-9193
1098-5530
DOI:10.1128/JB.00697-18