Telmisartan attenuates kidney apoptosis and autophagy-related protein expression levels in an intermittent hypoxia mouse model

Purpose Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a...

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Bibliographic Details
Published in:Sleep & breathing 2019-03, Vol.23 (1), p.341-348
Main Authors: Zhang, Xiao-Bin, Cai, Jing-Huang, Yang, Yu-Yun, Zeng, Yi-Ming, Zeng, Hui-Qing, Wang, Miao, Cheng, Xiao, Luo, Xiongbiao, Ewurum, Henry Chidozie
Format: Article
Language:English
Subjects:
Angiotensin II - blood
Animals
Apoptosis
Apoptosis - drug effects
Autophagy
Autophagy-Related Proteins - metabolism
Basic Science • Original
Basic Science • Original Article
Blood Urea Nitrogen
Body Weight - drug effects
Creatinine - blood
Dentistry
Disease Models, Animal
Hypoxia
Hypoxia - pathology
Hypoxia - physiopathology
In Situ Nick-End Labeling
Internal Medicine
Kidney - drug effects
Kidney - pathology
Male
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Neurology
Otorhinolaryngology
Pediatrics
Pneumology/Respiratory System
Telmisartan - pharmacology
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Summary:Purpose Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a mouse model of OSA. Materials and methods Mice were randomly allocated to normoxia, CIH, and CIH+telmisartan groups ( n  = 12 in each group). The CIH exposure duration was 12 weeks. Mice in the CIH+telmisartan group received telmisartan administration. The terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and western blotting of Bax and cleaved caspase-3 were conducted for evaluating apoptosis in kidney tissue. While the autophagy-related proteins, beclin-1 and LC3, were also observed via western blotting. Results The percentage of apoptotic cell in the CIH group was significantly higher than that of normoxia group; meanwhile, Bax and cleaved caspase-3 protein levels were increased in the CIH group than those of normoxia group (all p  
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-018-1720-9