Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans

During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.

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Bibliographic Details
Published in:Blood advances 2019-03, Vol.3 (5), p.724-728
Main Authors: van der Meer, Anne Jan, Kroeze, Anna, Hoogendijk, Arie J., Soussan, Aicha Ait, Ellen van der Schoot, C., Wuillemin, Walter A., Voermans, Carlijn, van der Poll, Tom, Zeerleder, Sacha
Format: Article
Language:English
Subjects:
Animals
Blood Cells - metabolism
Cell-Free Nucleic Acids - metabolism
Healthy Volunteers
Humans
Inflammation - pathology
Kinetics
Lipopolysaccharides
Male
Mice
Neutrophils - metabolism
Nucleosomes - metabolism
Parenchymal Tissue - cytology
Parenchymal Tissue - metabolism
Sepsis - blood
Severity of Illness Index
Stimulus Report
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Description
Summary:During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2018018895