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Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans
During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.
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Published in: | Blood advances 2019-03, Vol.3 (5), p.724-728 |
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container_title | Blood advances |
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creator | van der Meer, Anne Jan Kroeze, Anna Hoogendijk, Arie J. Soussan, Aicha Ait Ellen van der Schoot, C. Wuillemin, Walter A. Voermans, Carlijn van der Poll, Tom Zeerleder, Sacha |
description | During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells. |
doi_str_mv | 10.1182/bloodadvances.2018018895 |
format | article |
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subjects | Animals Blood Cells - metabolism Cell-Free Nucleic Acids - metabolism Healthy Volunteers Humans Inflammation - pathology Kinetics Lipopolysaccharides Male Mice Neutrophils - metabolism Nucleosomes - metabolism Parenchymal Tissue - cytology Parenchymal Tissue - metabolism Sepsis - blood Severity of Illness Index Stimulus Report |
title | Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans |
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