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Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans

During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.

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Published in:Blood advances 2019-03, Vol.3 (5), p.724-728
Main Authors: van der Meer, Anne Jan, Kroeze, Anna, Hoogendijk, Arie J., Soussan, Aicha Ait, Ellen van der Schoot, C., Wuillemin, Walter A., Voermans, Carlijn, van der Poll, Tom, Zeerleder, Sacha
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cited_by cdi_FETCH-LOGICAL-c479t-edae022bf25696bd5d37f92238260a177f36f7bf31b1084c25720bc7a5ca56d33
cites cdi_FETCH-LOGICAL-c479t-edae022bf25696bd5d37f92238260a177f36f7bf31b1084c25720bc7a5ca56d33
container_end_page 728
container_issue 5
container_start_page 724
container_title Blood advances
container_volume 3
creator van der Meer, Anne Jan
Kroeze, Anna
Hoogendijk, Arie J.
Soussan, Aicha Ait
Ellen van der Schoot, C.
Wuillemin, Walter A.
Voermans, Carlijn
van der Poll, Tom
Zeerleder, Sacha
description During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.
doi_str_mv 10.1182/bloodadvances.2018018895
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source ScienceDirect; PubMed (Medline)
subjects Animals
Blood Cells - metabolism
Cell-Free Nucleic Acids - metabolism
Healthy Volunteers
Humans
Inflammation - pathology
Kinetics
Lipopolysaccharides
Male
Mice
Neutrophils - metabolism
Nucleosomes - metabolism
Parenchymal Tissue - cytology
Parenchymal Tissue - metabolism
Sepsis - blood
Severity of Illness Index
Stimulus Report
title Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans
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