SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

An imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are ex...

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Bibliographic Details
Published in:The Malaysian journal of medical sciences 2019-01, Vol.26 (1), p.66-72
Main Authors: Samara, Tjam Diana, Liem, Isabella Kurnia, Prijanti, Ani Retno, Andrijono
Format: Article
Language:English
Subjects:
Blood pressure
Cell cycle
Cesarean section
Enzymes
Gestational age
Hypertension
Hypoxia
Original
Placenta
Preeclampsia
Pregnancy
Proteins
Signal transduction
Statistical analysis
Vagina
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Summary:An imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL1 levels in late-onset PE. This cross-sectional study included 50 patients with late-onset (≥ 32 weeks gestation) PE. Maternal serum was obtained before delivery, and placentas were obtained immediately after delivery. SEMA3B and CUL1 levels were evaluated by ELISA. Results were statistically analysed by Spearman correlation test, with a < 0.05 considered statistically significant. While elevated serum SEMA3B levels significantly correlated with increased placental SEMA3B levels in late-onset PE ( = 0.620, = 0.000), alteration of serum CUL1 levels did not correlate with alteration of placental CUL1. Alteration of circulating maternal SEMA3B, but not CUL1, levels can potentially be used to monitor PE progression during pregnancy.
ISSN:1394-195X
2180-4303
DOI:10.21315/mjms2019.26.1.6