The Serum Creatinine Level Might Be Associated with the Onset of Impaired Fasting Glucose: A Community-based Longitudinal Cohort Health Checkup Study

Objective Skeletal muscle is the main target organ for glycemic control, and the serum creatinine level is a convenient indicator of the skeletal muscle mass. This study aimed to assess the potential relationship between the serum creatinine level and the onset of impaired fasting glucose (IFG). Met...

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Published in:Internal Medicine 2019/02/15, Vol.58(4), pp.505-510
Main Authors: Yoshida, Naohiko, Miyake, Teruki, Yamamoto, Shin, Furukawa, Shinya, Senba, Hidenori, Kanzaki, Sayaka, Koizumi, Mitsuhito, Ishihara, Toru, Yoshida, Osamu, Hirooka, Masashi, Kumagi, Teru, Abe, Masanori, Kitai, Kohichiro, Matsuura, Bunzo, Hiasa, Yoichi
Format: Article
Language:English
Subjects:
Cohort analysis
community-based longitudinal cohort study
Creatinine
Fasting
Glucose
Glucose tolerance
Health risk assessment
impaired fasting glucose
Internal medicine
Intolerance
Kidney diseases
Muscles
Musculoskeletal system
Original
Risk factors
serum creatinine
Skeletal muscle
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Summary:Objective Skeletal muscle is the main target organ for glycemic control, and the serum creatinine level is a convenient indicator of the skeletal muscle mass. This study aimed to assess the potential relationship between the serum creatinine level and the onset of impaired fasting glucose (IFG). Methods In this large, community-based, retrospective longitudinal cohort study, we examined the records of 7,905 Japanese participants (3,863 men, 4,042 women) of 18-80 years of age who underwent annual health checkups at a single center between April 2003 and August 2013. After applying the exclusion criteria, 6,490 participants were reviewed to identify those with the onset of IFG, defined as a fasting plasma glucose ≥6.11 mM. Among the participants, 278 met the criterion for the onset of IFG during the observation period. Results Creatinine levels were higher in male subjects who exercised periodically and were exercise conscious in comparison to those who did not exercise, and were higher in female subjects who exercised periodically in comparison to female subjects who did not exercise and who were not exercise conscious. Additionally, the serum creatinine level was negatively associated with the onset of IFG in both men [adjusted hazard ratio, 0.98; 95% confidence interval (CI), 0.96-0.99; p=0.008] and women (adjusted hazard ratio, 0.94; 95% CI, 0.91-0.97; p
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0760-18