Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the second leading cause of death worldwide. In preclinical stroke models, NSCs have been shown to modulate inflammation, foster neuroplasticity...

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Bibliographic Details
Published in:Brain and behavior 2019-03, Vol.9 (3), p.e01214-n/a
Main Authors: Baker, Emily W., Kinder, Holly A., West, Franklin D.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
cell replacement
Clinical trials
Drug dosages
Humans
Medical prognosis
Neural stem cell
Neural Stem Cells - transplantation
Neurogenesis
Neurons - physiology
Neuroplasticity
neuroprotection
Neuroprotection - physiology
regenerative medicine
Regenerative Medicine - methods
Review
Reviews
Stem Cell Transplantation - methods
Stem cells
Stroke
Stroke - therapy
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Summary:Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the second leading cause of death worldwide. In preclinical stroke models, NSCs have been shown to modulate inflammation, foster neuroplasticity and neural reorganization, promote angiogenesis, and act as a cellular replacement by differentiating into mature neural cell types. However, there are several key technical questions to address before NSC therapy can be applied to the clinical setting on a large scale. Purpose of Review In this review, we will discuss the various sources of NSCs, their therapeutic modes of action to enhance stroke recovery, and considerations for the clinical translation of NSC therapies. Understanding the key factors involved in NSC‐mediated tissue recovery and addressing the current translational barriers may lead to clinical success of NSC therapy and a first‐in‐class restorative therapy for stroke patients. Transplanted neural stem cells (NSCs) have demonstrated multimodal therapeutic function after stroke. In preclinical stroke models, NSCs have been shown to modulate inflammation, foster neuroplasticity, and neural reorganization; promote angiogenesis; and act as a cellular replacement by differentiating into mature neural cell types. Understanding the key factors involved in NSC‐mediated tissue recovery and addressing the current translational barriers may lead to clinical success of NSC therapy and a first‐in‐class restorative therapy for stroke patients.
ISSN:2162-3279
2162-3279
DOI:10.1002/brb3.1214