Effect of peptide-conjugated nanoparticles on cell lines

Metal nanoparticles are widely used for the delivery and targeting of pharmaceutical, therapeutic and diagnostic agents in cancer therapy in recent years. The multifunctional nanoparticles constructed currently are supposed to show superior effects on cancer cells. This study was conducted to observ...

Full description

Saved in:
Bibliographic Details
Published in:Progress in biomaterials 2019-03, Vol.8 (1), p.11-21
Main Authors: Banerjee, Kangkana, Ravishankar Rai, V., Umashankar, M.
Format: Article
Language:English
Subjects:
Apoptosis
Biological effects
Biomaterials
Biotechnology
Breast cancer
Cancer
Chemical compounds
Chemistry and Materials Science
Colon
Colon cancer
Conjugates
Conjugation
Deoxyribonucleic acid
Diagnostic agents
Diagnostic systems
Disintegration
DNA
DNA fragmentation
Fluorescence
Fluorescent dyes
Fluorescent indicators
Gold
Lethality
Materials Science
Nanoparticles
Original Research
Peptides
Pharmacology
Silver
Tumor cell lines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metal nanoparticles are widely used for the delivery and targeting of pharmaceutical, therapeutic and diagnostic agents in cancer therapy in recent years. The multifunctional nanoparticles constructed currently are supposed to show superior effects on cancer cells. This study was conducted to observe the difference between the effect of a biologically important peptide, silver (AgNPs) and gold (AuNPs) nanoparticles and their conjugates on two different cancer cells. Peptide (Boc-L- D P-L-OMe) was acquired from different sources and subjected to conjugation with biosynthesized gold and silver nanoparticles under standard conditions. These conjugates were tested against the colon cancer (HT-29) and breast cancer (MDA MB-231) cell lines. The results clearly depicted the improved activity of nanoparticles in the form of conjugates. Fluorescent dye microscopy and DNA fragmentation assay substantiate the fact that the conjugated nanoparticles cause higher level of disintegration of DNA in cells that consecutively damages and causes apoptosis due to lethality.
ISSN:2194-0509
2194-0517
DOI:10.1007/s40204-019-0106-9