Recent Development of Catalytic Trifluoromethoxylation Reactions

Trifluoromethoxy (OCF3) group exhibits unique properties, which render it a highly desirable structural motif in life and materials sciences. The numbers of newly synthesized trifluoromethyl ethers are booming as new synthetic methods are constantly being developed to access these valuable compounds...

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Bibliographic Details
Published in:Tetrahedron 2018-12, Vol.74 (50), p.7127-7135
Main Authors: Lee, Katarzyna N., Lee, Johnny W., Ngai, Ming-Yu
Format: Article
Language:English
Subjects:
Fluorine
Photoredox catalysis
Radical
Transition metal catalysis
Trifluoromethoxylation
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Summary:Trifluoromethoxy (OCF3) group exhibits unique properties, which render it a highly desirable structural motif in life and materials sciences. The numbers of newly synthesized trifluoromethyl ethers are booming as new synthetic methods are constantly being developed to access these valuable compounds. This Review summarizes recent catalytic approaches towards preparation of trifluoromethyl ethers. Alkene, allylic, benzylic, and aryl trifluoromethoxylation reactions are discussed herein. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.09.020