Dynamic changes of pulmonary arterial pressure in perinatal neonates with pulmonary and extrapulmonary acute lung injury/respiratory distress syndrome

• Published in: Medicine (Baltimore) 2019-03, Vol.98 (11), p.e14830-e14830
• Main Authors: Yin, Tong-jin, Hu, Yu-Sheng, Cheng, Sheng, Yong, Qi-Jun
• Format: Article
• Language: English
• Subjects: Acute Lung Injury - diagnosis; Acute Lung Injury - physiopathology; Arterial Pressure; China; Correlation of Data; Female; Humans; Hypertension, Pulmonary - diagnosis; Infant, Newborn; Male; Monitoring, Physiologic - methods; Observational Study; Pulmonary Artery - diagnostic imaging; Pulmonary Artery - physiopathology; Respiratory Distress Syndrome, Newborn - diagnosis; Respiratory Distress Syndrome, Newborn - physiopathology; Retrospective Studies; Severity of Illness Index; Ultrasonography, Doppler, Color - methods
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000014830

This study aims to explore the dynamic changes of pulmonary arterial pressure (PAP) and its clinical significance in prenatal neonates with pulmonary and extra-pulmonary acute lung injury/respiratory distress syndrome (ALI/ARDS).A prospective study was conducted in the Neonate Intensive Care Unit (NICU) between May 2015 and April 2017. A total of 78 prenatal neonates with ALI/ARDS were selected and divided into 2 groups: pulmonary group (n = 37) and extra-pulmonary group (n = 41). These neonates were further divided into 3 groups according to the OSI index: mild, moderate, and severe groups. The dynamic changes of PAP were observed in these neonates. In the moderate and severe groups, PAP was significantly higher in neonates with pulmonary ALI/ADDS (ALI/ARDSp) than in neonates with extrapulmonary ALI/ARDS(ALI/ARDSexp) (62.5 ± 5.4 vs 68.0 ± 6.5, 54.7 ± 5.9 vs 64.2 ± 4.9; t = 3.264, 3.123; P = .004,.039). Furthermore, PAP was higher in neonates with ALI/ADDSp in the severe group, compared with those in the moderate group (t = 2.420, P