Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats

• Published in: International journal of environmental research and public health 2019-03, Vol.16 (5), p.830
• Main Authors: Park, Se Hwan, Yoon, Jin Hwan, Seo, Dae Yun, Kim, Tae Nyun, Ko, Jeong Rim, Han, Jin
• Format: Article
• Language: English
• Subjects: Adenosine; Adenosine kinase; Adenosine monophosphate; Aerobics; Animals; Antioxidants - metabolism; Blood Glucose; Body Weight; Body weight gain; Climbing; Cyclic AMP-Dependent Protein Kinases - metabolism; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - therapy; Energy Intake; Exercise; Feeding behavior; Fitness training programs; Food; Food intake; Glucagon; Glucagon - metabolism; Glucagon-Like Peptide-1 Receptor - metabolism; Glucose; Glucose tolerance; Glucose Transporter Type 2 - metabolism; Hindbrain; Hyperglycemia; Hypothalamus; Hypothalamus - metabolism; Insulin; Insulin resistance; Kinases; Leptin; Male; Physical fitness; Physical training; Protein kinase; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats; Resistance Training - methods; Weight control
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph16050830

The aim of this study was to investigate the effects of resistance exercise training on hypothalamic GLP-1R levels and its related signaling mechanisms in T2DM. The animals were separated into three groups: a non-diabetic control (CON), diabetic control (DM), and diabetic with resistance exercise (DM + EXE) group. The resistance exercise training group performed ladder climbing (eight repetitions, three days per week for 12 weeks). Body weight was slightly lower in the DM + EXE group than the DM group, but difference between the groups was not significant. Food intake and glucose were significantly lower in the DM + EXE group than in the DM group. The blood insulin concentration was significantly higher and glucagon was significantly lower in the DM + EXE group. The DM + EXE group in the hypothalamus showed significant increases in GLP-1R mRNA, protein kinase A (PKA), glucose transporter 2 (GLUT2), and protein kinase B (AKT) and significant decrease in protein kinase C-iota (PKC-iota). Antioxidant enzymes and apoptosis factors were significantly improved in the DM + EXE group compared with the DM group in the hypothalamus. The results suggest that resistance exercise contributes to improvements the overall health of the brain in diabetic conditions.