Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers

Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer...

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Bibliographic Details
Published in:Polymers 2016-08, Vol.8 (8), p.303
Main Authors: Wald, Sarah, Wurm, Frederik R, Landfester, Katharina, Crespy, Daniel
Format: Article
Language:English
Subjects:
Communication
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Summary:Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition⁻fragmentation chain transfer (RAFT) polymerization, which consists in a homopolymer with triisopropylsilyl protecting groups. The protecting groups ensure the efficient stabilization of the inverse (water-in-oil, w/o) miniemulsions. Nanocapsules can be formed and the protecting group can be subsequently cleaved for the re-dispersion of nanocapsules in an aqueous medium with a minimal amount of additional surfactant.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym8080303