Novel Wet Micro-Contact Deprinting Method for Patterning Gold Nanoparticles on PEG-Hydrogels and Thereby Controlling Cell Adhesion

In the present work we introduce a novel method to create linear and rectangular micro-patterns of gold nanoparticles (Au NPs) on poly(ethylene glycol) (PEG) hydrogels. The strategy consists of removing Au NPs from defined regions of the silicon wafer by virtue of the swelling effect of the hydrogel...

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Bibliographic Details
Published in:Polymers 2017-05, Vol.9 (5), p.176
Main Authors: Yesildag, Cigdem, Bartsch, Christoph, De Vicente, Gonzalo, Lensen, Marga C
Format: Article
Language:English
Subjects:
Biomedical engineering
Biomedical materials
Cell adhesion
Coating
Fibroblasts
Gold
Hydrogels
Nanocomposites
Nanoparticles
Optical properties
Patterning
Polyethylene glycol
Raman spectra
Resonance scattering
Scattering
Silicon
Swelling
Tissue engineering
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Summary:In the present work we introduce a novel method to create linear and rectangular micro-patterns of gold nanoparticles (Au NPs) on poly(ethylene glycol) (PEG) hydrogels. The strategy consists of removing Au NPs from defined regions of the silicon wafer by virtue of the swelling effect of the hydrogel. Using this method, which we denote as "Wet Micro-Contact Deprinting", well-defined micro-patterns of Au NPs on silicon can be created. This resulting pattern is then transferred from the hard substrate to the soft surface of PEG-hydrogels. These unique micro- and nano-patterned hydrogels were cultured with mouse fibroblasts L929 cells. The cells selectively adhered on the Au NPs coated area and avoided the pure PEG material. These patterned, nanocomposite biointerfaces are not only useful for biological and biomedical applications, such as tissue engineering and diagnostics, but also, for biosensor applications taking advantage of surface plasmon resonance (SPR) or surface enhanced Raman scattering (SERS) effects, due to the optical properties of the Au NPs.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym9050176