The evolution of practical radiobiological modelling

A summary of the key aspects of radiobiological modelling is provided, based on the theoretical and practical concepts of the linear quadratic model, which gradually replaced other numerical approaches. The closely related biological effective dose concept is useful in many clinical applications. Bi...

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Bibliographic Details
Published in:British journal of radiology 2019, Vol.92 (1093), p.20180097
Main Authors: Jones, B, Dale, R G
Format: Article
Language:English
Subjects:
Dose-Response Relationship, Radiation
Forecasting
Humans
Models, Biological
Patient Safety
Proton Therapy - methods
Pushing the frontiers of radiobiology: A special feature in memory of Sir Oliver Scott and Professor Jack Fowler: Review
Radiation Injuries - prevention & control
Radiation Tolerance
Radiobiology - methods
Radiobiology - trends
Radiotherapy Dosage
Relative Biological Effectiveness
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Summary:A summary of the key aspects of radiobiological modelling is provided, based on the theoretical and practical concepts of the linear quadratic model, which gradually replaced other numerical approaches. The closely related biological effective dose concept is useful in many clinical applications. Biological effective dose formulations in conventional photon-based radiotherapy continue to be developed, and can be extended to the now increasingly used proton and ion-beam therapy, to very low or high dose ranges, the dose rate effect, hypoxia and repopulation. Such established and new research developments will be of interest to clinicians, physicists and biologists to better understand the processes underlying radiotherapy and assist their collaborative efforts to make radiotherapy safer and more effective.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.20180097