LC‑MS/MS proteomic analysis revealed novel associations of 37 proteins with T2DM and notable upregulation of immunoglobulins

Type 2 diabetes mellitus (T2DM) is a disease associated with a number of metabolic disturbances, including protein metabolism. In the present study, blood samples were obtained from Bahraini subjects, including 6 patients with T2DM and 6 age- and sex-matched, non-diabetic, healthy controls. Depleted...

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Bibliographic Details
Published in:International journal of molecular medicine 2019-05, Vol.43 (5), p.2118-2132
Main Authors: Abdulwahab, Rabab Asghar, Alaiya, Ayodele, Shinwari, Zakia, Allaith, Abdul Ameer A, Giha, Hayder A
Format: Article
Language:English
Subjects:
Analysis
Ankylosing spondylitis
Biological markers
Biomarkers
Cell adhesion & migration
Chromatography
Chronic illnesses
Diabetes
Diabetes mellitus
Fasting
Glucose
Hemoglobin
Immunoglobulins
Insulin
Liquid chromatography
Males
Mass spectrometry
Metabolism
Novels
Peptides
Physiological aspects
Proteins
Proteomics
RNA polymerase
Scientific imaging
Signal transduction
Software
Spectroscopy
Type 2 diabetes
Variance analysis
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Summary:Type 2 diabetes mellitus (T2DM) is a disease associated with a number of metabolic disturbances, including protein metabolism. In the present study, blood samples were obtained from Bahraini subjects, including 6 patients with T2DM and 6 age- and sex-matched, non-diabetic, healthy controls. Depleted and non-depleted sera were prepared from the collected blood, and the global protein expression changes were evaluated by liquid chromatography tandem mass spectrometry. Only significantly and markedly differentially-expressed proteins (P
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2019.4127