Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents

The Mucorales fungi—formerly classified as the zygomycetes—are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often d...

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Bibliographic Details
Published in:Mycopathologia (1975) 2019-02, Vol.184 (1), p.121-128
Main Authors: Thielen, Beth K., Barnes, Aaron M. T., Sabin, Arick P., Huebner, Becky, Nelson, Susan, Wesenberg, Elizabeth, Hansen, Glen T.
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - administration & dosage
Antifungal agents
Antifungal Agents - administration & dosage
Antiparasitic agents
Biomedical and Life Sciences
Burns
Burns - complications
Care and treatment
Debridement
Dermatomycoses - diagnosis
Dermatomycoses - microbiology
Dermatomycoses - pathology
Dermatomycoses - therapy
Disease transmission
Eukaryotic Microbiology
Fungi
Fungicides
Health aspects
Humans
Immunocompromised host
Infection
Infections
Lichtheimia
Life Sciences
Male
Medical Microbiology
Medical schools
Microbial Ecology
Microbiology
Middle Aged
Morbidity
Mucorales
Mucorales - classification
Mucorales - isolation & purification
Mucormycosis - diagnosis
Mucormycosis - microbiology
Mucormycosis - pathology
Mucormycosis - therapy
Nitriles - administration & dosage
Original Paper
Patients
Plant Sciences
Pyridines - administration & dosage
Skin
Treatment Outcome
Triazoles - administration & dosage
Type 2 diabetes
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Summary:The Mucorales fungi—formerly classified as the zygomycetes—are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often despite surgical and antifungal therapy. Patients with extensive burn injuries are particularly susceptible to skin and soft-tissue infections with these organisms. Here, we present a case of Lichtheimia infection in a patient with extensive full-thickness burns that required significant and repeated surgical debridement successfully treated with isavuconazole and adjunctive topical amphotericin B washes. We also review the available literature on contemporary antifungal treatment for Lichtheimia species and related Mucorales fungi.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-018-0281-6