Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Aim To compare the differences of glucose metabolism outcomes between treatment‐naïve, patients with first episode psychosis (FEP) and mood disorders. Methods We conducted a systematic review and meta‐analysis of glucose intolerance in treatment‐naïve, first episode patients with severe mental illne...

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Bibliographic Details
Published in:Early intervention in psychiatry 2019-10, Vol.13 (5), p.1021-1031
Main Authors: Kucukgoncu, Suat, Kosir, Urska, Zhou, Elton, Sullivan, Erin, Srihari, Vinod H., Tek, Cenk
Format: Article
Language:English
Subjects:
Diabetes
Diabetes Mellitus - metabolism
Disorders
Emotional disorders
Evidence-based medicine
first episode
Glucose
Glucose - metabolism
Glucose Tolerance Test
Humans
Illnesses
Insulin
Insulin Resistance
Mental disorders
Meta-analysis
Metabolism
mood disorders
Mood Disorders - metabolism
Psychosis
Psychotic Disorders - metabolism
Systematic review
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Summary:Aim To compare the differences of glucose metabolism outcomes between treatment‐naïve, patients with first episode psychosis (FEP) and mood disorders. Methods We conducted a systematic review and meta‐analysis of glucose intolerance in treatment‐naïve, first episode patients with severe mental illnesses (SMIs). Results We identified 31 eligible studies. Compared to healthy controls, FEP group have higher insulin and insulin resistance levels, and both groups have higher glucose tolerance test results. No significant differences were found in glucose metabolism outcomes between FEP and mood disorder groups. Conclusions Our results highlight impaired glucose metabolism at the onset of SMIs, suggesting both patients with psychosis and mood disorders are high‐risk groups for diabetes development.
ISSN:1751-7885
1751-7893
DOI:10.1111/eip.12749