Leukopenia induced by micafungin in a bottlenose dolphin (Tursiops truncatus): a case report

A bottlenose dolphin (Tursiops truncatus) housed in the Port of Nagoya Public Aquarium (PNPA) presented with symptomatic pneumonia caused by Aspergillus fumigatus. The dolphin was treated with micafungin. On days 2 and 11 after the first administration of micafungin, results from a physical examinat...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2019, Vol.81(3), pp.449-453
Main Authors: OHNO, Yoshito, AKUNE, Yuichiro, NITTO, Hiroshi, INOSHIMA, Yasuo
Format: Article
Language:English
Subjects:
Animal cognition
Aquatic mammals
Body temperature
bottlenose dolphin
Case reports
Colony-stimulating factor
Dolphins & porpoises
fungal pneumonia
G-CSF
Granulocyte colony-stimulating factor
Laboratory tests
Leukocytes (granulocytic)
Leukocytes (neutrophilic)
Leukopenia
Marine mammals
Micafungin
Tursiops truncatus
Wildlife Science
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Summary:A bottlenose dolphin (Tursiops truncatus) housed in the Port of Nagoya Public Aquarium (PNPA) presented with symptomatic pneumonia caused by Aspergillus fumigatus. The dolphin was treated with micafungin. On days 2 and 11 after the first administration of micafungin, results from a physical examination and laboratory test indicated a decline of body temperature (BT) and leukopenia, with lowest BT, white blood cells (WBCs), and segmented neutrophils (SEGs) of 34.2°C, 600 cells/µl, and 67 cells/µl, respectively. BT, WBCs, and SEGs returned to normal range after administration of granulocyte colony stimulating factor (G-CSF). To the best of our knowledge, this is the first report of micafungin-induced decline of BT and leukopenia that was successfully treated with G-CSF in a bottlenose dolphin.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.18-0391