Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans: Genomic Prediction

In this Review, we focus on the similarity of the concepts underlying prediction of estimated breeding values (EBVs) in livestock and polygenic risk scores (PRS) in humans. Our research spans both fields and so we recognize factors that are very obvious for those in one field, but less so for those...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 2019-04, Vol.211 (4), p.1131-1141
Main Authors: Wray, Naomi R, Kemper, Kathryn E, Hayes, Benjamin J, Goddard, Michael E, Visscher, Peter M
Format: Article
Language:English
Subjects:
Animals
Big Data
Breeding - methods
Genome-Wide Association Study - methods
Genomic Prediction
Humans
Livestock - genetics
Multifactorial Inheritance
Quantitative Trait, Heritable
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this Review, we focus on the similarity of the concepts underlying prediction of estimated breeding values (EBVs) in livestock and polygenic risk scores (PRS) in humans. Our research spans both fields and so we recognize factors that are very obvious for those in one field, but less so for those in the other. Differences in family size between species is the wedge that drives the different viewpoints and approaches. Large family size achievable in nonhuman species accompanied by selection generates a smaller effective population size, increased linkage disequilibrium and a higher average genetic relationship between individuals within a population. In human genetic analyses, we select individuals unrelated in the classical sense (coefficient of relationship
ISSN:0016-6731
1943-2631
DOI:10.1534/genetics.119.301859