Light-Switchable Ion Channels and Receptors for Optogenetic Interrogation of Neuronal Signaling

Optogenetics is an emerging technique that enables precise and specific control of biological activities in defined space and time. This technique employs naturally occurring or engineered light-responsive proteins to manipulate the physiological processes of the target cells. To better elucidate th...

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Bibliographic Details
Published in:Bioconjugate chemistry 2018-04, Vol.29 (4), p.861-869
Main Authors: Lin, Wan-Chen, Kramer, Richard H
Format: Article
Language:English
Subjects:
Animals
Biological activity
Cells
Cysteine - genetics
Cysteine - metabolism
Genetics
Humans
Information processing
Interrogation
Ion channels
Ion Channels - genetics
Ion Channels - metabolism
Ions
Light
Molecular biology
Molecular chains
Neurons
Neurons - metabolism
Neurotransmitter receptors
Optics
Optogenetics - methods
Organic chemistry
Photochemical Processes
Protein Engineering - methods
Proteins
Receptors
Receptors, GABA-A - genetics
Receptors, GABA-A - metabolism
Receptors, Glutamate - genetics
Receptors, Glutamate - metabolism
Receptors, Neurotransmitter - genetics
Receptors, Neurotransmitter - metabolism
Signal Transduction
Signaling
Topical Review
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Summary:Optogenetics is an emerging technique that enables precise and specific control of biological activities in defined space and time. This technique employs naturally occurring or engineered light-responsive proteins to manipulate the physiological processes of the target cells. To better elucidate the molecular bases of neural functions, substantial efforts have been made to confer light sensitivity onto ion channels and neurotransmitter receptors that mediate signaling events within and between neurons. The chemical strategies for engineering light-switchable channels/receptors and the neuronal implementation of these tools are discussed.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.7b00803