Long-term follow-up of patients with Buerger's disease after autologous stem cell therapy

We investigated the long-term results of autologous bone marrow mononuclear cells (ABMMNCs) implantation in patients with Buerger's disease (BD). Twenty-eight patients (25 males and 3 females) who had BD and critical unilateral limb ischemia were investigated between April 2003 and August 2005....

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Bibliographic Details
Published in:Anatolian journal of cardiology 2019-03, Vol.21 (3), p.155-162
Main Authors: Baran, Çağdaş, Durdu, Serkan, Özçınar, Evren, Çakıcı, Mehmet, Hasde, Ali İhsan, İnan, Bahadır, Şırlak, Mustafa, Akar, Rüçhan
Format: Article
Language:English
Subjects:
Angiogenesis
Ankle
Bone marrow
Investigations
Ischemia
Medical imaging
Original Investigation
Pain
Proteins
Quality of life
Stem cells
Transplants & implants
Ulcers
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Summary:We investigated the long-term results of autologous bone marrow mononuclear cells (ABMMNCs) implantation in patients with Buerger's disease (BD). Twenty-eight patients (25 males and 3 females) who had BD and critical unilateral limb ischemia were investigated between April 2003 and August 2005. The patients were administered multiple injections of CD34+ and CD45+ positive ABMMNCs into the gastrocnemius muscle, the intermetatarsal region, and the dorsum of the foot (n=26) or forearm (n=2) and saline injection into the contralateral limb. The mean follow-up time was 139.6±10.5 months. No complication related to stem cell therapy was observed during the follow-up. The ankle-brachial pressure index evaluated at 6 months and 120 months was compared to the baseline scores (p
ISSN:2149-2263
2149-2271
DOI:10.14744/AnatolJCardiol.2018.12354