Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults

This is the protocol for a review and there is no abstract. The objectives are as follows: The overall objective is to assess the effects of pharmacological interventions for prevention of insufficiency fractures associated with pelvic radiotherapy in adults. Primary objective To assess the effects...

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Bibliographic Details
Published in:Cochrane database of systematic reviews 2013-06, Vol.2013 (6)
Main Authors: Mehmood, Qurrat U, Garcez, Kate, Henson, Caroline C, Davidson, Susan E, Higham, Claire E
Format: Article
Language:English
Subjects:
Medicine General & Introductory Medical Sciences
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Summary:This is the protocol for a review and there is no abstract. The objectives are as follows: The overall objective is to assess the effects of pharmacological interventions for prevention of insufficiency fractures associated with pelvic radiotherapy in adults. Primary objective To assess the effects of pharmacological interventions on insufficiency fractures and avascular necrosis of the femoral head after curative pelvic radiotherapy in adults. Secondary objectives To assess the effects of pharmacological interventions on bone mineral density and fracture risk in adults after curative pelvic radiotherapy. To assess the effects of pharmacological interventions on quality of life (QoL) and bone symptoms in adults after curative pelvic radiotherapy. To assess the effects of pharmacological interventions on unplanned hospital stay and mortality in adults undergoing curative pelvic radiotherapy. To identify adverse effects of pharmacological interventions. To compare different types of pharmacological interventions.
ISSN:1469-493X
DOI:10.1002/14651858.CD010604