Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure

Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently obs...

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Bibliographic Details
Published in:Scientific reports 2019-04, Vol.9 (1), p.6015, Article 6015
Main Authors: Sieber-Ruckstuhl, Nadja S., Burla, Bo, Spoerel, Susanne, Schmid, Florence, Venzin, Claudio, Cazenave-Gassiot, Amaury, Bendt, Anne K., Torta, Federico, Wenk, Markus R., Boretti, Felicitas S.
Format: Article
Language:English
Subjects:
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Adipogenesis
Animals
Arteriosclerosis
Cardiovascular diseases
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Dogs
Dyslipidemia
Environmental Exposure - adverse effects
Female
Glucocorticoids
Glucocorticoids - adverse effects
Humanities and Social Sciences
Hyperlipidemia
Hypertension
Immunosuppressive agents
Inflammation
Lipid metabolism
Lipidomics
Lipids - blood
Lipolysis
Male
Metabolic disorders
Metabolism
multidisciplinary
Phenotype
Science
Science (multidisciplinary)
Time Factors
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Summary:Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently observed consequence of GC treatment, typified by increased lipolysis, lipid mobilization, liponeogenesis, and adipogenesis. Dogs with excess GC show hyperlipidaemia, hypertension, and a higher risk of developing type 2 diabetes mellitus, but the risk of developing atherosclerotic lesions is low as compared to humans. This study aimed to examine alterations in the canine plasma lipidome in a model of experimentally induced short-term and long-term GC excess. Both treatments led to significant plasma lipidome alterations, which were more pronounced after long-term excess steroid exposure. In particular, monohexosylceramides, phosphatidylinositols, ether phosphatidylcholines, acyl phosphatidylcholines, triacylglycerols and sphingosine 1-phosphates showed significant changes. The present study highlights the hitherto unknown effects of GCs on lipid metabolism, which will be important in the further elucidation of the role and function of GCs as drugs and in metabolic and cardiovascular diseases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-42190-1