CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors

Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors. In this retrospective study, im...

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Bibliographic Details
Published in:Journal of clinical and experimental dentistry 2019-03, Vol.11 (3), p.e213-e218
Main Authors: Ranjbar, Mohammad-Ali, Ranjbar, Zahra, Zahed, Maryam, Nikookar, Negar
Format: Article
Language:English
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Summary:Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors. In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Labeling indices of CD73 expression were calculated and compared between lesions. Immunohistochemical analysis demonstrated that the CD73 expression was significantly higher in salivary gland tumors than in normal salivary gland tissue (
ISSN:1989-5488
1989-5488
DOI:10.4317/jced.54918