An updated understanding of the mechanisms involved in chemotherapy-induced neuropathy

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The symptoms, which include pain, numbness, tingling and loss of motor function, can result in therapy titrations that compromi...

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Bibliographic Details
Published in:Pain management (London) 2018-09, Vol.8 (5), p.363-375
Main Authors: Boyette-Davis, Jessica A, Hou, Saiyun, Abdi, Salahadin, Dougherty, Patrick M
Format: Article
Language:English
Subjects:
Cancer therapies
Chemotherapy
cytokine
Cytokines
Diabetes
Inhibitor drugs
ion channels
Kinases
Melatonin
mitochondria
neuropathy
neurotransmission
Pain
Pain management
Peripheral neuropathy
Potassium
Quality of life
Review
Systematic review
TNF inhibitors
Tumor necrosis factor-TNF
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Summary:The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The symptoms, which include pain, numbness, tingling and loss of motor function, can result in therapy titrations that compromise therapy efficacy. Understanding the mechanisms of chemotherapy-induced peripheral neuropathy is therefore essential, yet incompletely understood. The literature presented here will address a multitude of molecular and cellular mechanisms, beginning with the most well-understood cellular and molecular-level changes. These modifications include alterations in voltage-gated ion channels, neurochemical transmission, organelle function and intracellular pathways. System-level alterations, including changes to glial cells and cytokine activation are also explored. Finally, we present research on the current understanding of genetic contributions to this condition. Suggestions for future research are provided.
ISSN:1758-1869
1758-1877
DOI:10.2217/pmt-2018-0020