The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation

To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methyl...

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Bibliographic Details
Published in:Epigenomics 2018-11, Vol.10 (11), p.1445-1461
Main Authors: Bush, Nicole R, Edgar, Rachel D, Park, Mina, MacIsaac, Julia L, McEwen, Lisa M, Adler, Nancy E, Essex, Marilyn J, Kobor, Michael S, Boyce, W Thomas
Format: Article
Language:English
Subjects:
Adults
Adverse Childhood Experiences
Biomarkers
Child
Child, Preschool
Children
Children & youth
CpG Islands
Deoxyribonucleic acid
DNA
DNA Methylation
Embedding
Environmental health
Epigenetics
Epithelial cells
Ethnicity
Female
Females
Gene expression
Genes
Genome, Human
Genomes
Humans
Male
Preschool education
Psychopathology
Socioeconomic Factors
Socioeconomic status
Socioeconomics
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Summary:To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2018-0042