Cell circuits and niches controlling B cell development

Summary Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small sub...

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Bibliographic Details
Published in:Immunological reviews 2019-05, Vol.289 (1), p.142-157
Main Authors: Zehentmeier, Sandra, Pereira, João P.
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Animals
B-Lymphocytes - physiology
cell circuits
Cell Differentiation
Cells (biology)
Cellular Microenvironment
Chemokine CXCL12 - metabolism
Chemokines
Circuits
CXCL12
Cytokines
Endothelial cells
Endothelial Cells - physiology
hematopoiesis
Hematopoietic stem cells
Hematopoietic Stem Cells - physiology
Humans
interleukin 7
Interleukin-7 - metabolism
Interleukins
Leukemia
Lymphocytes B
Lymphoid cells
lymphoid commitment
Lymphopoiesis
Mesenchymal Stem Cells - physiology
Mesenchyme
Microenvironments
Progenitor cells
Stem cell factor
Stem Cell Niche
Stem cells
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Summary:Summary Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. Niche cells create specialized microenvironments through the concomitant production of short‐range acting cell‐fate determining cytokines such as interleukin (IL)‐7 and stem cell factor and the potent chemoattractant C‐X‐C motif chemokine ligand 12. This type of cellular organization allows for the cross‐talk between hematopoietic stem and progenitor cells with niche cells, such that niche cell activity can be regulated by the quality and quantity of hematopoietic progenitors being produced. For example, preleukemic B cell progenitors and preB acute lymphoblastic leukemias interact directly with MPCs, and downregulate IL‐7 expression and the production of non‐leukemic lymphoid cells. In this review, we discuss a novel model of B cell development that is centered on cellular circuits formed between B cell progenitors and lymphopoietic niches.
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12749