Benefits of Hesperidin for Cutaneous Functions

Hesperidin is a bioflavonoid, with high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated multiple benefits of hesperidin for cutaneous functions, including wound healing, UV p...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2019-01, Vol.2019 (2019), p.1-19
Main Authors: Man, Mao-Qiang, Elias, Peter M., Yang, Bin
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Cancer
Cardiovascular system
Care and treatment
Cell cycle
Citrus fruits
Cosmetics industry
Diabetes mellitus
Endoplasmic reticulum
Evidence-based medicine
Hesperidin
Homeostasis
Inflammation
MAP kinase
Oxidative stress
Pasteurization
Permeability
Prevention
Review
Skin
Skin care products
Sunscreens (Cosmetics)
Wound healing
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Summary:Hesperidin is a bioflavonoid, with high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated multiple benefits of hesperidin for cutaneous functions, including wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer, and skin lightening. In addition, hesperidin enhances epidermal permeability barrier homeostasis in both normal young and aged skin. The mechanisms by which hesperidin benefits cutaneous functions are attributable to its antioxidant properties, inhibition of MAPK-dependent signaling pathways, and stimulation of epidermal proliferation, differentiation, and lipid production. Because of its low cost, wide availability, and superior safety, hesperidin could prove useful for the management of a variety of cutaneous conditions.
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/2676307