Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential

Proteins have sparked fast growing interest as biological therapeutic agents for several diseases. Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracel...

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Bibliographic Details
Published in:Bioconjugate chemistry 2019-04, Vol.30 (4), p.1028-1041
Main Authors: Singh, Khushboo, Ejaz, Wardah, Dutta, Kingshuk, Thayumanavan, S
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies - administration & dosage
Antibodies - therapeutic use
Cell membranes
Cell-Penetrating Peptides - administration & dosage
Chemical compounds
Drug Delivery Systems
Humans
Immunogenicity
Immunoglobulins
Immunotherapy
Intracellular
Liposomes
Medical treatment
Nanoparticles
Pharmacology
Topical Review
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Summary:Proteins have sparked fast growing interest as biological therapeutic agents for several diseases. Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracellular targets, their use in targeting therapeutically important intracellular targets is limited by their inability to cross cellular membrane. Realizing the potential for antibody therapy in disease treatment, progress has been made in the development of methods to deliver antibodies intracellularly. In this review, we address various platforms for delivery of antibodies and their merits and drawbacks.
ISSN:1043-1802
1520-4812
1520-4812
DOI:10.1021/acs.bioconjchem.9b00025