Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes?

Epigenetic modifications have an important role to explain part of the intra- and inter-species variation in gene expression. They also have a role in the control of transposable elements (TEs) whose activity may have a significant impact on genome evolution by promoting various mutations, which are...

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Bibliographic Details
Published in:Genes 2019-03, Vol.10 (3), p.249
Main Authors: Lannes, Romain, Rizzon, Carène, Lerat, Emmanuelle
Format: Article
Language:English
Subjects:
Conservation
Divergence
DNA methylation
DNA Transposable Elements
Epigenesis, Genetic
Epigenetics
Evolution
Evolution, Molecular
Gene duplication
Gene expression
Genes, Duplicate
Genetics
Genomes
Human genetics
Humans
Life Sciences
Multigene Family
Proteins
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Summary:Epigenetic modifications have an important role to explain part of the intra- and inter-species variation in gene expression. They also have a role in the control of transposable elements (TEs) whose activity may have a significant impact on genome evolution by promoting various mutations, which are expected to be mostly deleterious. A change in the local epigenetic landscape associated with the presence of TEs is expected to affect the expression of neighboring genes since these modifications occurring at TE sequences can spread to neighboring sequences. In this work, we have studied how the epigenetic modifications of genes are conserved and what the role of TEs is in this conservation. For that, we have compared the conservation of the epigenome associated with human duplicated genes and the differential presence of TEs near these genes. Our results show higher epigenome conservation of duplicated genes from the same family when they share similar TE environment, suggesting a role for the differential presence of TEs in the evolutionary divergence of duplicates through variation in the epigenetic landscape.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes10030249