Glycomacropeptide Bioactivity and Health: A Review Highlighting Action Mechanisms and Signaling Pathways

Food-derived bioactive peptides are reported as beneficial and safe for human health. Glycomacropeptide (GMP) is a milk-protein-derived peptide that, in addition to its nutritional value, retains many biological properties and has therapeutic effects in several inflammatory disorders. GMP was shown...

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Bibliographic Details
Published in:Nutrients 2019-03, Vol.11 (3), p.598
Main Authors: Córdova-Dávalos, Laura Elena, Jiménez, Mariela, Salinas, Eva
Format: Article
Language:English
Subjects:
bioactive properties
Colorectal cancer
gastrointestinal system
glycopeptides
human health
immune system
Lipopolysaccharides
mechanism of action
nutritive value
physiology
Review
signal transduction
therapeutics
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Summary:Food-derived bioactive peptides are reported as beneficial and safe for human health. Glycomacropeptide (GMP) is a milk-protein-derived peptide that, in addition to its nutritional value, retains many biological properties and has therapeutic effects in several inflammatory disorders. GMP was shown under in vitro and in vivo conditions to exert a number of activities that regulate the physiology of important body systems, namely the gastrointestinal, endocrine, and immune systems. This review represents a comprehensive compilation summarizing the current knowledge and updated information on the major biological properties associated with GMP. GMP bioactivity is addressed with special attention on mechanisms of action, signaling pathways involved, and structural characteristics implicated. In addition, the results of various studies dealing with the effects of GMP on models of inflammatory diseases are reviewed and discussed.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11030598