Permittivity of ex vivo healthy and diseased murine skeletal muscle from 10 kHz to 1 MHz

• Published in: Scientific data 2019-04, Vol.6 (1), p.37-37, Article 37
• Main Authors: Nagy, J. A., DiDonato, C. J., Rutkove, S. B., Sanchez, B.
• Format: Article
• Language: English
• Subjects: 631/1647/334/1874/345; 631/57/2266; 692/617/375/374; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - physiopathology; Animal models; Animals; Data Descriptor; Data processing; Diabetes mellitus; Diabetes Mellitus, Experimental - physiopathology; Disease Models, Animal; Electric Capacitance; Gastrocnemius muscle; Humanities and Social Sciences; Hypertrophy; Mice; multidisciplinary; Muscle, Skeletal - physiology; Muscular Atrophy, Spinal - physiopathology; Muscular dystrophy; Muscular Dystrophy, Animal - physiopathology; Musculoskeletal system; Neuromuscular diseases; Science; Science (multidisciplinary); Skeletal muscle; Spinal muscular atrophy
• ISSN: 2052-4463; 2052-4463
• DOI: 10.1038/s41597-019-0045-2

A better understanding of the permittivity property of skeletal muscle is essential for the development of new diagnostic tools and approaches for neuromuscular evaluation. However, there remain important knowledge gaps in our understanding of this property in healthy and diseased skeletal muscle, which hinder its translation into clinical application. Here, we report the permittivity of gastrocnemius muscle in healthy wild type mice and murine models of spinal muscular atrophy, muscular dystrophy, diabetes, amyotrophic lateral sclerosis and in a model of myofiber hypertrophy. Data were measured ex vivo from 10 kHz to 1 MHz using the four-electrode impedance technique. Additional quantitative histology information were obtained. Ultimately, the normative data reported will offer the scientific community the opportunity to develop more accurate models for the validation and prediction of experimental observations in both pre-clinical and clinical neuromuscular disease research. Design Type(s) physiological data analysis objective • strain comparison design • ex vivo design Measurement Type(s) permittivity property Technology Type(s) impedance analyzer Factor Type(s) temporal_instant • frequency • Mouse Model • experimental condition Sample Characteristic(s) Mus musculus • skeletal muscle tissue Machine-accessible metadata file describing the reported data (ISA-Tab format)