Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration

Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an...

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Bibliographic Details
Published in:Chemical engineering & technology 2018-12, Vol.41 (12), p.2418-2426
Main Authors: Kochendoerfer, Kiara, Sa Gomes, Pedro, Rütze, Dennis N., Pathapati, Trinath, Wit, Pieter, Zaalberg, Menne
Format: Article
Language:English
Subjects:
Bipolar electrodialysis
Electrodialysis
Fermentation
Hybrid system
Moving beds
Regeneration
Simulated moving bed
Streams
Technology integration
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Summary:Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ‐aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product‐containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation. Effective donwnstream processing units are mandatory for complex streams in bio‐based industries. Simulated moving‐bed chromatography can improve process efficiency by reducing resin and buffer requirement and be further enhanced by hybridization. Such system was successfully integrated with bipolar electrodialysis for purification of γ‐aminobutyric acid from a clarified fermentation broth.
ISSN:0930-7516
1521-4125
DOI:10.1002/ceat.201800298