The role of HLA- A 33:01 in Patients with Cholestatic Hepatitis attributed to Terbinafine

Example: A ribbon diagram demonstrating docking of a terbinafine molecule in the protein binding cleft of HLA-A * 33:01 (blue), HLA-B * 14:02 (green), and HLA-C * 08:02 locus. A locus in the human leukocyte antigen gene (HLA-A *33:01, B*14:02, C * 08:02) was significantly overrepresented in Caucasia...

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Bibliographic Details
Published in:Journal of hepatology 2018-08, Vol.69 (6), p.1317-1325
Main Authors: Fontana, Robert John, Cirulli, Elizabeth Theresa, Gu, Jiezhun, Kleiner, David, Ostrov, David, Phillips, Elizabeth, Schutte, Ryan, Barnhart, Huiman, Chalasani, Naga, Watkins, Paul Brent, Hoofnagle, Jay H.
Format: Article
Language:English
Online Access:Get full text
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Summary:Example: A ribbon diagram demonstrating docking of a terbinafine molecule in the protein binding cleft of HLA-A * 33:01 (blue), HLA-B * 14:02 (green), and HLA-C * 08:02 locus. A locus in the human leukocyte antigen gene (HLA-A *33:01, B*14:02, C * 08:02) was significantly overrepresented in Caucasian and African American patients with liver injury attributed to terbinafine compared to population controls. These data along with the molecular docking studies demonstrate that this genetic polymorphism is a plausible risk factor for developing terbinafine hepatotoxicity and could be used in the future to help doctors make a diagnosis more rapidly and confidently.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2018.08.004