Exploring Matrix Effects on Binding Properties and Characterization of Cotinine Molecularly Imprinted Polymer on Paper-Based Scaffold

Commercially available sorbent materials for solid-phase extraction are widely used in analytical laboratories. However, non-selective binding is a major obstacle for sample analysis. To overcome this problem, molecularly imprinted polymers (MIPs) were used as selective adsorbent materials prior to...

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Bibliographic Details
Published in:Polymers 2019-03, Vol.11 (3), p.570
Main Authors: Larpant, Nutcha, Suwanwong, Yaneenart, Boonpangrak, Somchai, Laiwattanapaisal, Wanida
Format: Article
Language:English
Subjects:
Adsorption
Binding sites
Chromatography
Composite materials
Fiberglass
Imprinted polymers
Isotherms
Laboratories
Mass spectrometry
Materials selection
Mathematical analysis
Membranes
Nicotine
Outdoor air quality
Polymerization
Polymers
Scaffolds
Scientific imaging
Selective binding
Selectivity
Smoking
Solid phases
Sorbents
Tobacco
Tobacco smoke
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Summary:Commercially available sorbent materials for solid-phase extraction are widely used in analytical laboratories. However, non-selective binding is a major obstacle for sample analysis. To overcome this problem, molecularly imprinted polymers (MIPs) were used as selective adsorbent materials prior to determining target analysts. In this study, the use of non-covalent molecularly imprinted polymers (MIPs) for cotinine adsorption on a paper-based scaffold was studied. Fiberglass paper was used as a paper scaffold for cotinine-selective MIP adsorption with the use of 0.5% agarose gel. The effects of salt, pH, sample matrix, and solvent on the cotinine adsorption and extraction process were investigated. Under optimal conditions, the adsorption isotherm of synthesized MIPs increased to 125.41 µg/g, whereas the maximum adsorption isotherm of non-imprinted polymers (NIPs) was stable at 42.86 µg/g. The ability of the MIP paper scaffold to absorb cotinine in water medium was approximately 1.8⁻2.8-fold higher than that of the NIP scaffold. From Scatchard analysis, two dissociation constants of MIPs were calculated to be 2.56 and 27.03 µM. Nicotine, myosmine, and N-nitrosonornicotine were used for selectivity testing, and the calculated selectivity factor of cotinine to nicotine, myosmine, and N-nitrosonornicotine was 1.56, 2.69, and 2.05, respectively. Overall, the MIP paper scaffold is promising for simple onsite sampling of cotinine and can be used to assess tobacco smoke exposure.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym11030570