Line-Field Optical Coherence Tomography as a tool for In vitro characterization of corneal biomechanics under physiological pressures

There has been a lot of interest in accurately characterising corneal biomechanical properties under intraocular pressure (IOP) to help better understand ocular pathologies that are associated with elevated IOP. This study investigates the novel use of Line-Field Optical Coherence Tomography (LF-OCT...

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Bibliographic Details
Published in:Scientific reports 2019-04, Vol.9 (1), p.6321-6321, Article 6321
Main Authors: Kazaili, Ahmed, Lawman, Samuel, Geraghty, Brendan, Eliasy, Ashkan, Zheng, Yalin, Shen, Yaochun, Akhtar, Riaz
Format: Article
Language:English
Subjects:
639/166/985
639/624/1107/510
Animals
Biomechanics
Cornea
Cornea - diagnostic imaging
Cornea - physiopathology
Deformation
Elastic Modulus
Elastic properties
Humanities and Social Sciences
Hydration
Hysteresis
Intraocular Pressure
Mechanical properties
multidisciplinary
Physiology
Pressure
Science
Science (multidisciplinary)
Swine
Tomography
Tomography, Optical Coherence
Tonometry, Ocular
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Summary:There has been a lot of interest in accurately characterising corneal biomechanical properties under intraocular pressure (IOP) to help better understand ocular pathologies that are associated with elevated IOP. This study investigates the novel use of Line-Field Optical Coherence Tomography (LF-OCT) as an elastographic tool for accurately measuring mechanical properties of porcine corneas based on volumetric deformation following varying IOPs. A custom-built LF-OCT was used to measure geometrical and corneal surface displacement changes in porcine corneas under a range of IOPs, from 0–60 mmHg. Corneal thickness, elastic properties and hysteresis were calculated as a function of pressure. In addition, the effects of hydration were explored. We found that the elastic modulus increased in a linear fashion with IOP. Corneal thickness was found to reduce with IOP, decreasing 14% from 0 to 60 mmHg. Prolonged hydration in phosphate buffered saline (PBS) was found to significantly increase the elastic modulus and corneal hysteresis. Our study demonstrates that LF-OCT can be used to accurately measure the elastic properties based on volumetric deformation following physiological pressures. Furthermore, we show that prolonged hydration in PBS has a significant effect on the measured corneal properties.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-42789-4