Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation

Lycopene is a dietary antioxidant known to prevent skin photodamage. This study aimed to examine age‐dependent presence of this carotenoid on the surface of the facial skin and in the serum as well as to measure the same parameters during supplementation with lycopene. Serum samples and samples from...

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Bibliographic Details
Published in:Food science & nutrition 2019-04, Vol.7 (4), p.1157-1165
Main Authors: Petyaev, Ivan M., Pristensky, Dmitry V., Morgunova, Elena Y., Zigangirova, Nailya A., Tsibezov, Valeriy V., Chalyk, Natalia E., Klochkov, Victor A., Blinova, Victoria V., Bogdanova, Tatiana M., Iljin, Alexei A., Sulkovskaya, Larisa S., Chernyshova, Marina P., Lozbiakova, Marina V., Kyle, Nigel H., Bashmakov, Yuriy K.
Format: Article
Language:English
Subjects:
Age
Age factors
aging
antioxidant carotenoid
Antioxidants
Biopsy
Body mass index
Cardiology
Carotenoids
Collaboration
Diet
dietary supplementation
Dietary supplements
Employees
Epidemiology
Fluorescence
High-performance liquid chromatography
Isomers
Levels
Liquid chromatography
Lycopene
Monoclonal antibodies
Original Research
serum lycopene isomers
Skin
skin surface
Studies
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Summary:Lycopene is a dietary antioxidant known to prevent skin photodamage. This study aimed to examine age‐dependent presence of this carotenoid on the surface of the facial skin and in the serum as well as to measure the same parameters during supplementation with lycopene. Serum samples and samples from facial skin surface were obtained from 60 young (under 25 years old) and 60 middle‐aged (over 50 years old) volunteers. Similar samples were taken from 15 middle‐aged subjects during 4‐week supplementation with lycopene (7 mg/day). Serum lycopene levels and isomer profiles were analyzed by HPLC. Lycopene in desquamated corneocytes and the sebum from facial skin surface was determined using lycopene‐specific fluorescent monoclonal antibodies. The results demonstrated that there was no age‐related difference in serum lycopene levels, but a higher proportion of (all‐E)‐lycopene was detected in the “young” group (37.5% vs 26.2% in the “middle‐aged” group; p 
ISSN:2048-7177
2048-7177
DOI:10.1002/fsn3.799