Association of genetic variation of the six gene prognostic model for castration‐resistant prostate cancer with survival

Background We previously identified a blood RNA transcript‐based model consisting of six immune or inflammatory response genes (ABL2, SEMA4D, ITGAL, C1QA, TIMP1, and CDKN1A) that was prognostic for survival in cohorts of men with castration‐resistant prostate cancer (CRPC). We investigated whether i...

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Bibliographic Details
Published in:The Prostate 2019-01, Vol.79 (1), p.73-80
Main Authors: Xie, Wanling, Stopsack, Konrad H., Drouin, Sarah J., Fu, Henry, Pomerantz, Mark M., Mucci, Lorelei A., Lee, Gwo‐Shu M., Kantoff, Philip W.
Format: Article
Language:English
Subjects:
Aged
Alleles
Blood
Castration
castration‐resistant prostate cancer
Cohort Studies
Diagnosis
Follow-Up Studies
Genetic Association Studies - methods
Genetic diversity
Genetic Variation - genetics
Genotyping
Humans
Inflammation
Male
Medical prognosis
Metastases
Middle Aged
Polymorphism, Single Nucleotide - genetics
Prognosis
Prostate cancer
Prostatic Neoplasms, Castration-Resistant - diagnosis
Prostatic Neoplasms, Castration-Resistant - genetics
Prostatic Neoplasms, Castration-Resistant - mortality
Ribonucleic acid
RNA
Single-nucleotide polymorphism
SNP
Survival
Survival Rate - trends
Tissue inhibitor of metalloproteinase 1
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Summary:Background We previously identified a blood RNA transcript‐based model consisting of six immune or inflammatory response genes (ABL2, SEMA4D, ITGAL, C1QA, TIMP1, and CDKN1A) that was prognostic for survival in cohorts of men with castration‐resistant prostate cancer (CRPC). We investigated whether inherited variation in these six genes was associated with overall survival (OS) in men with CRPC. Methods The test cohort comprised 600 patients diagnosed with CRPC between 1996 and 2011 at Dana‐Farber Cancer Institute. Genotyping of 66 tagging single nucleotide polymorphisms (SNPs) spanning the six genes was performed on blood derived DNAs. For the top four SNPs (P
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.23712