Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes

Objectives The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie diet (VLCD) and subsequent bariatric weigh...

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Bibliographic Details
Published in:European radiology 2019-05, Vol.29 (5), p.2474-2480
Main Authors: Fazeli Dehkordy, Soudabeh, Fowler, Kathryn J., Mamidipalli, Adrija, Wolfson, Tanya, Hong, Cheng William, Covarrubias, Yesenia, Hooker, Jonathan C., Sy, Ethan Z., Schlein, Alexandra N., Cui, Jennifer Y., Gamst, Anthony C., Hamilton, Gavin, Reeder, Scott B., Sirlin, Claude B.
Format: Article
Language:English
Subjects:
Bariatric Surgery - adverse effects
Biopsy
Body weight loss
Coding
Cross-Sectional Studies
Data processing
Diagnostic Radiology
Fatty liver
Fatty Liver - diagnosis
Fatty Liver - etiology
Female
Gastrointestinal
Humans
Hypocaloric diet
Imaging
Internal Medicine
Interventional Radiology
Liver
Liver - pathology
Lobes
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Nutrient deficiency
Obesity, Morbid - surgery
Organic chemistry
Patients
Postoperative Complications
Postoperative period
Prospective Studies
Proton density (concentration)
Radiology
Reduction
Regression analysis
Reproducibility of Results
Secondary analysis
Segments
Steatosis
Surgery
Ultrasound
Weight loss
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Summary:Objectives The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie diet (VLCD) and subsequent bariatric weight loss surgery (WLS). Methods We performed a secondary analysis of data from 118 morbidly obese adult patients enrolled in a VLCD-WLS program. PDFF was estimated using magnitude-based confounder-corrected chemical-shift-encoded (CSE) MRI in each hepatic segment and lobe at baseline (visit 1), after completion of VLCD (visit 2), and at 1, 3, and 6 months (visits 3–5) following WLS. Linear regressions were used to estimate the rate of PDFF change across visits. Lobar and segmental rates of change were compared pairwise. Results Baseline PDFF was significantly higher in the right lobe compared to the left lobe ( p  
ISSN:0938-7994
1432-1084
1432-1084
DOI:10.1007/s00330-018-5894-0